منابع مشابه
Protein flexibility and intrinsic disorder.
Comparisons were made among four categories of protein flexibility: (1) low-B-factor ordered regions, (2) high-B-factor ordered regions, (3) short disordered regions, and (4) long disordered regions. Amino acid compositions of the four categories were found to be significantly different from each other, with high-B-factor ordered and short disordered regions being the most similar pair. The hig...
متن کاملProtein flexibility, not disorder, is intrinsic to molecular recognition
An 'intrinsically disordered protein' (IDP) is assumed to be unfolded in the cell and perform its biological function in that state. We contend that most intrinsically disordered proteins are in fact proteins waiting for a partner (PWPs), parts of a multi-component complex that do not fold correctly in the absence of other components. Flexibility, not disorder, is an intrinsic property of prote...
متن کاملIntrinsic Protein Disorder and Protein-Protein Interactions
Intrinsically disordered proteins often bind to more than one partner. In this study, we focused on 11 sets of complexes in which the same disordered segment becomes bound to two or more distinct partners. For this collection of protein complexes, two or more partners of each disordered segment were selected to have less than 25% amino acid identity at structurally aligned positions. As it tur...
متن کاملIntrinsic disorder and protein function.
2 The dominant view of protein structure-function is that an amino acid sequence specifies a (mostly) fixed three-dimensional (3-D) structure that is a prerequisite to protein function. In contrast to the dominant view, many proteins display functions requiring the disordered state. Our purpose here is to provide a catalogue of disorder-function relationships. The very important molecular detai...
متن کاملProtein intrinsic disorder in plants
To some extent contradicting the classical paradigm of the relationship between protein 3D structure and function, now it is clear that large portions of the proteomes, especially in higher organisms, lack a fixed structure and still perform very important functions. Proteins completely or partially unstructured in their native (functional) form are involved in key cellular processes underlain ...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2004
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.03128904